Panimun Bioral 100mg Solution

INTRODUCTION

PANIMUN BIORAL 100MG SOLUTION contains Cyclosporine which belongs to the group of medicines called Immunosuppressants. It is used to prevent graft rejection in patients undergoing transplantation of any organ, bone marrow or stem cells. It can also be used to treat various auto-immune disease conditions such as psoriasis, atopic dermatitis (or eczema), rheumatoid arthritis (joint inflammation) or nephrotic syndrome (a kidney disease). It is mostly used in combination with other immune suppressants (such as azathioprine) to achieve maximum benefits. Take PANIMUN BIORAL 100MG SOLUTION regularly as instructed by your doctor. While undergoing therapy with PANIMUN BIORAL 100MG SOLUTION your doctor will periodically monitor your blood pressure, blood cholesterol levels, liver and kidney functions to avoid the risk of side effects. Your doctor may also prescribe you blood tests and urine tests at regular intervals to access the improvement in your health conditions. During treatment with PANIMUN BIORAL 100MG SOLUTION, avoid exposing your skin towards direct sunlight. Wear protective loose-fitting clothes and apply sunscreen while going outdoors. Before taking PANIMUN BIORAL 100MG SOLUTION inform your doctor if you have any liver problems or any signs of infections (such as fever or sore throat). You must also inform your doctor if you have hepatitis C infection, fits, low blood magnesium levels, gout, alcohol dependence or if you are about to receive any vaccinations as a precaution. PANIMUN BIORAL 100MG SOLUTION is not recommended for use in patients with severe uncontrollable infections, any types of cancer or severe high blood pressure. Do not take PANIMUN BIORAL 100MG SOLUTION without consulting your doctor if you are pregnant or breastfeeding. Avoid consuming grapefruit or drinking grapefruit juice while taking PANIMUN BIORAL 100MG SOLUTION as it may increase the risk of side effects. The most common side effects of taking PANIMUN BIORAL 100MG SOLUTION are increase in blood sugar levels, increase in blood cholesterol levels, increased blood potassium levels, high blood pressure, headache, loss of appetite, acne, hot flushes, tiredness, excessive facial hair and low blood magnesium levels in blood. Consult your doctor if any of these side effects worsen.

USES OF PANIMUN BIORAL 100MG SOLUTION

• Prevents graft rejection following organ transplantation
• Treats auto-immune skin diseases such as psoriasis or atopic dermatitis
• Treats rheumatoid arthritis (joint inflammation)
• Treat nephrotic syndrome (a kidney disease)

HOW PANIMUN BIORAL 100MG SOLUTION WORKS

PANIMUN BIORAL 100MG SOLUTION is an immunosuppressive agent. It works by blocking the release of certain chemicals in the body (such as T-cells, interleukins and cytokines) that triggers the immune response. This action suppresses your body’s immune functions and enables your body to accept the newly transplanted organ. It also stops the abnormal immune response in the body and prevents your body from attacking its own cells.

DIRECTIONS FOR USE

Take PANIMUN BIORAL 100MG SOLUTION as directed by your physician. Shake well before use. Measure the required amount of the medicine in the measuring cup provided with the pack. Consume the medicine orally after measuring. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition. Do not stop taking PANIMUN BIORAL 100MG SOLUTION without consulting your doctor.

SIDE EFFECTS OF PANIMUN BIORAL 100MG SOLUTION

HOW TO MANAGE SIDE EFFECTS

Nausea or vomiting: Try to take PANIMUN BIORAL 100MG SOLUTION with or just after meals. Stick to simple meals and avoid oil rich or spicy foods. Consult your doctor if nausea worsens. Headache:   Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as water or electrolytes. Applying a pain-relieving balm on your forehead can be beneficial. Do not consume excessive alcohol, as it could aggravate your headache. Consult your doctor if your headache worsens.

WARNING & PRECAUTIONS

INTERACTIONS

A. Drug – Drug interactions: Before taking PANIMUN BIORAL 100MG SOLUTION, inform your doctor if you are taking any of the following medicines such as:

• St. John’s Wort (an herbal medicine used to treat depression)
• Dabigatran etexilate (a medicine used to prevent blood clots after surgery)
• Bosentan or aliskiren (medicines used to treat high blood pressure)
• Vaccines
• Medicines that can increase blood potassium levels in the body (such as potassium supplements or potassium-sparing diuretics (Ex. amiloride, triamterene or spironolactone))
• Methotrexate (a medicine used to treat cancer and severe rheumatoid arthritis)
• Medicines used to treat bacterial infections (Ex. erythromycin, azithromycin, gentamycin, tobramycin, ciprofloxacin)
• Medicines used to treat fungal infections (Ex. voriconazole, itraconazole, terbinafine, amphotericin B)
• Medicines used for heart problems or high blood pressure (Ex. diltiazem, nicardipine, verapamil, digoxin, amiodarone)
• Metoclopramide (a medicine used to stop nausea and vomiting)
• Danazol (a medicine used to treat overgrowth in the uterus)
• Oral contraceptives (birth control pills) Ex. ethinylestradiol
• Medicines used to treat gout (Ex. colchicine, allopurinol)
• Medicines used to treat gallstones (Ex. ursodiol)
• Medicines used to treat leukaemia and other cancers (Ex. imatinib, melphalan, etoposide, doxorubicin)
• Barbiturates (used to reduce anxiety and to induce sleep) Ex. phenobarbital
• Medicines used to treat epilepsy (Ex. carbamazepine, phenytoin, cannabidiol)
• Octreotide (a medicine used to treat hormonal disorder, (acromegaly) and tumours)
• Orlistat (a medicine that helps in weight loss)
• Ticlopidine (a medicine used to prevent blood clots due to platelet aggregation)
• Other medicines used to supress immune system (Ex. everolimus, sirolimus, tacrolimus)
• Medicine used to reduce pain and inflammation Ex. diclofenac
• Medicines used to lower cholesterol levels (Ex. fenofibrate, atorvastatin, Fluvastatin)
• Medicines used to treat tuberculosis (Ex. isoniazid, rifampicin)
• Medicines used to treat HIV infections (Ex. acyclovir, ritonavir, nelfinavir, saquinavir, efavirenz, etravirine, nevirapine)
• Medicines used to treat hepatitis C infection (Ex. telaprevir, boceprevir, the combination ombitasvir/paritaprevir/ritonavir with or without dasabuvir, elbasvir/grazoprevir and glecaprevir/pibrentasvir)
• Medicines used to treat gastric problems (Ex. omeprazole, cimetidine, magnesium hydroxide, aluminum hydroxide)
• Trimethoprim or cotrimoxazole (used to treat bacterial infections)
• Corticosteroids (used to treat allergic or autoimmune diseases) Ex. prednisolone, methylprednisolone
• Medicines used to treat diabetes (Ex. repaglinide)

B. Drug – food interactions Avoid consuming grapes or grapefruit juice while taking PANIMUN BIORAL 100MG SOLUTION as it may increase the risk of side effects.

Overdosage:

If you or anyone else accidentally took more PANIMUN BIORAL 100MG SOLUTION, consult your doctor immediately or visit the nearby hospital. Symptoms of overdosage might include vomiting, drowsiness, headache, fast heartbeat and kidney damage.