XARELTO 20mg Tablet

INTRODUCTION

XARELTO 20MG TABLET contains Rivaroxaban, which belongs to the group of medicines called Antithrombotic agents. It is used to treat deep vein thrombosis (DVT), pulmonary embolism (PE), and venous thromboembolism (VTE). It is also used to reduce the risk of stroke, systemic embolism in nonvalvular atrial fibrillation, recurrence of DVT or PE, major cardiovascular events in patients with coronary artery disease (CAD), and major thrombotic vascular events in patients with peripheral artery disease (PAD). Venous thromboembolism is a condition that occurs due to clot formation in the venous circulation. It can also be used for THE prevention of DVT in patients undergoing knee or hip replacement surgery, VTE in acutely ill medical patients, and thrombosis in children (older than 2 years) with congenital heart disease post the Fontan procedure. Before taking XARELTO 20MG TABLET, inform your doctor if you have any liver, kidney, or bleeding problems or antiphospholipid syndrome. XARELTO 20MG TABLET is not recommended for use in pregnant or breast-feeding women, so consult your doctor before taking it. XARELTO 20MG TABLET is not studied and is not recommended in children less than 6 months of age who were less than 37 weeks of growth at birth, had less than 10 days of oral feeding, or weigh less than 2.6 kg. XARELTO 20MG TABLET should be used with caution in elderly patients (65 years or older). Consult your doctor before taking it. The most common side effects of taking XARELTO 20MG TABLET are bleeding, pain and swelling in the limbs, fever, stomach pain, indigestion, nausea, vomiting, constipation, diarrhea, low blood pressure (feeling dizzy or fainting when standing up), weakness, tiredness, headache, dizziness, rash, and itchy skin. Contact your doctor if any of your symptoms worsen.

USES OF XARELTO 20MG TABLET

It is used:

• Treats deep vein thrombosis (DVT), pulmonary embolism (PE), venous thromboembolism (VTE)
• Reduces the risk of stroke, systemic embolism in nonvalvular atrial fibrillation, recurrence of DVT or PE, major cardiovascular events in patients with coronary artery disease (CAD), and major thrombotic vascular conditions in patients with peripheral artery disease (PAD)
• Prevention of DVT in patients undergoing knee or hip replacement surgery, VTE in acutely ill medical patients, and thrombosis in children (2 years and older) with congenital heart disease post the Fontan procedure

HOW XARELTO 20MG TABLET WORKS

XARELTO 20MG TABLET works by competitively inhibiting factor Xa (a clotting factor) and preventing the progression of the coagulation cascade through the final common pathway, thus preventing thrombin generation.

DIRECTIONS FOR USE

Take XARELTO 20MG TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition. Do not stop taking XARELTO 20MG TABLET unless your doctor advises.

SIDE EFFECTS OF XARELTO 20MG TABLET

HOW TO MANAGE SIDE EFFECTS

Stomach pain: Try to rest and relax. Eat and drink slowly or try to have smaller meals more frequently. Keep a heat pad on your stomach. If the symptom does not improve, contact your doctor. Nausea: Take XARELTO 20MG TABLET with, or just after meals. Stick to simple meals. Avoid eating oily or spicy foods. Vomiting: Get adequate rest. Drink lots of fluids, especially water. Have small sips if you feel sick. Eat when you feel like it – you do not need to eat or avoid any specific foods. Do not take any medicine other than XARELTO 20MG TABLET without asking your doctor. Constipation: Eat plenty of fiber rich foods such as fresh fruits, vegetables, and cereals and drink plenty of water. Exercise more regularly. Diarrhea: Drink lots of fluids, such as water or fruit juice to keep yourself hydrated. Do not consume any medicine other than XARELTO 20MG TABLET without consulting your doctor. Headache: Drink ample amount of water. Get adequate rest. Try to be relaxed and stress free. Ask your doctor before taking any medicine for headache. Dizziness: Lie down until dizziness is gone, then get up slowly. Move slowly and carefully, do not hurry. Get adequate rest. Drink plenty of water and other fluids. Avoid coffee, cigarettes, alcohol, and drugs.

WARNING & PRECAUTIONS

INTERACTIONS

A. Drug – Drug interactions: Before taking XARELTO 20MG TABLET, inform your doctor if you are taking any of the following medicine:

• Medicines used for fungal infections (Ex. fluconazole, itraconazole, voriconazole, posaconazole), unless they are used on the skin
• Ketoconazole (used to treat Cushing’s syndrome)
• Medicines used for bacterial infections (Ex. clarithromycin, erythromycin, rifampicin)
• Medicines used for HIV infection (Ex. ritonavir, indinavir)
• Other medicines used to reduce blood clotting (Ex. enoxaparin, clopidogrel, warfarin, apixaban, heparin, acenocoumarol, prasugrel, ticagrelor)
• Medicines used to treat inflammation and pain (Ex. naproxen, acetylsalicylic acid)
• Dronedarone (used to treat abnormal heartbeat)
• Medicines used to treat depression (Ex. citalopram, fluoxetine, venlafaxine, duloxetine, St. John’s wort)
• Medicines used to treat fits (Ex. carbamazepine, phenytoin, phenobarbital)

Overdosage:

If you or anyone else accidentally take too much of XARELTO 20MG TABLET, consult your doctor immediately or visit the nearby hospital. Symptom of overdose include bleeding.